Cancer has been fought on 1000 battlefields since 1971 and the fight goes on.
Excited to see the remarkable story of cancer research and its impact on cancer care and health presented in episode two of "Emperor of All Maladies." Public recognition of the brilliance and hard work of so many dedicated researchers and clinicians is long overdue.
Fisher challenged the dogma that cutting more would increase chance of cure in breast cancer, but it was biology that mattered.
The empirical approach to therapy went far but eventually it was realized we needed to gain basic knowledge of cancer.
Peyton Rous found a viral cause of cancer in chickens that revolutionized our understanding of cancer.
Dennis Burkitt in 1950's described an aggressive lymphoma in Africa that Epstein and Barr linked to a virus.
No viruses emerged as causes of the major killers lung, colon, and breast cancer but HPV was found and later a vaccine developed.
1775 Percivall Pott: scrotal cancers suggested a chemical cause of cancer in chimney sweepers; later cigarette smoking linked to cancer
Many explanations were offered as causes of cancer in smokers before a direct link was suspected.
Obesity and cancer may ultimately be seen in a light similar to tobacco and cancer.
The first segment of the three part series evokes intense emotions in viewers. It helps to juxtapose the historical challenges with the modern therapies, successful and sometimes not, with compassion and sensitivity. Personally, it is wonderful to see my past colleagues whom I knew personally and who contributed to my career in its early stages, and who bequeathed a generation of fine laboratory, translational and clinical scientists whose work and achievements are today curing so many patients. Kudos to the producers for part 1.
Ames associated mutagenesis with carcinogenesis; chemicals that caused mutations could cause cancer.
Bishop & Varmus showed that the src oncogene could cause cancer; the gene came from a normal counterpart in chickens.
That Ras, the most commonly mutated oncogene, remains an unsolved drug target highlights the challenges -- and enormous opportunities -- that remain for the field.
Knowing the oncogenes is a first step to get to new treatments for cancer.
Bailar a statistician pointed out that more people were dying each year despite basic science progress.
Cancer prevention and increased doses of chemotherapy with BMT seemed reasonable approaches to cancer in late 1980s.
Farber's choice of aminopterin was due to hi observation that leukemia patients given folic acid seemed to die more rapidly. So he decided to use and anti-folic acid and aminopterin (and later methotrexate) were used in his trials.
BMT for breast cancer was eventually shown to do more harm than good due to toxicity and the disease also relapsed.
Dr. Juliano at UCLA recognized that if the sentinel lymph node is negative surgery could be even less radical & preserve nodes.
Slamon believed in targeting oncogenes such as Her2 in breast cancer therapy.
Rowley, Druker, Sawyer studied the Philadelphia Chromosome discovered years earlier at Fox Chase Cancer Center.
Here we go. This has been an incredible series the first two nights - so informative and emotional. Can't wait to see the final chapter.
Vogelstein compared the cancer DNA to normal DNA to unravel the genetics of colon cancer.
The human genome project provided the sequence of the normal human genome that could be compared with cancer.
The Cancer Genome Atlas (TCGA) catalogued complex alterations in thousands of human tumors.
We should make common cause - within our field, with our patients, and with the public - to turn what was once a trickle of discoveries and is now a steady stream of monumental advances into a flood of progress. Having the story told, and told well, is an important achievement and an important step in that direction.
New targeted therapies for ALK can make patients feel better quickly but eventually resistance develops.
Patients like Gomez are the true heroes of oncology. Taking that fight to the unknown and incurring the risks associated with a new or experimental therapy, where the benefit may not even be for you but rather for those who follow you, takes incredible courage.
The second decade of targeted therapies for cancer saw incremental advances with failures and resistance despite billions spent.
The high cost of cancer care has become a major challenge for our time.
A very powerful insight by Dr Suzanne Cole: "Healing is not always eternal life, healing is sometimes helping people have a good death. There’s some kind of healing in that too."
Thank you to all who participated in this Medscape: Live Chat on Cancer: The Emperor of All Maladies. Your time and comments on the film are very much appreciated!